向原在瘤细胞外基质中的向作为癌症免疫治疗中新的向策略
Jiayang Liu1,2, Danjie Pan1,2,3, Xuan Huang1,2,3
1Department of Biological Medicines at School of Pharmacy, Minhang Hospital, Fudan University, Shanghai, China.
Frontiers in oncology
|September 11, 2023
概括
瘤原蛋白在细胞外基质中丰富,作为免疫疗法药物的标. 向原蛋白可以提高药物积累和有效性,同时减少副作用.
科学领域:
- 生物化学 生物化学
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 原蛋白是哺乳动物中最丰富的蛋白质,存在于组织,器官和瘤细胞外基质中.
- 瘤原蛋白积聚在肌层和内皮下,暴露在碎片化的瘤血管中.
- 增强的透性和保留 (EPR) 效应使原结合性大分子能够准瘤原蛋白.
研究的目的:
- 审查原结合域 (CBD) 或蛋白质 (CBP).
- 探索它们在瘤向免疫治疗中的机制和应用.
- 讨论这个领域的未来发展.
主要方法:
- 关于癌症免疫疗法中的原向研究的文献综述.
- 对原结合域和蛋白质的分析.
- 检查它们在药物输送和治疗疗效中的作用.
主要成果:
- 向瘤细胞外基质 (TEM) 原增强免疫疗法药物积累和保留.
- 在原向疗法中观察到抗瘤疗效的提高.
- 减少严重的不良影响与向瘤原蛋白有关.
结论:
- 瘤原蛋白是增强癌症免疫治疗的可行目标.
- 原结合域和蛋白质为药物输送提供了有希望的策略.
- 对CBD/CBP应用的进一步研究可能会彻底改变癌症治疗.
相关概念视频
02:17The Tumor Microenvironment
6.7K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.7K
01:27Tumor Immunotherapy
554
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
554
02:57Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
01:30Cancer Vaccines
399
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
399
02:38Mitogens and the Cell Cycle
6.5K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.5K