利用免疫系统:一种有效的方式来管理扩散型大B细胞淋巴瘤
Nathan Visweshwar1, Juan Felipe Rico2, Robert Killeen3
1Department of Hematology, University of South Florida, Tampa, FL, USA.
Journal of hematology
|September 11, 2023
概括
免疫疗法,包括rituximab和CAR T细胞疗法,正在改变扩散性大B细胞淋巴瘤 (DLBCL) 治疗. 新型药物提供了对耐火DLBCL的希望,尽管仍然存在挑战.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
背景情况:
- 扩散性大B细胞淋巴瘤 (DLBCL) 是一种复杂的血液癌症,受瘤微环境的影响.
- 免疫因素是DLBCL的行为和治疗策略的核心.
研究的目的:
- 审查免疫剂在DLBCL管理中的演变和影响.
- 讨论针对复发性/耐药性DLBCL的新兴免疫疗法.
主要方法:
- 在Medline,Embase,Cochrane数据库和临床指南的文献搜索.
- 包括2010年3月至2022年10月的研究,重点研究DLBCL免疫疗法.
主要成果:
- 利图西马布标志着DLBCL治疗的显著进展.
- 新型免疫疗法,包括CAR T细胞疗法,正在重塑复发/耐药病例的护理.
结论:
- 免疫学方法是现代DLBCL治疗的基石.
- 尽管取得了进展,但克服DLBCL中的阻力和耐火状态仍然是一个关键的挑战.
- 未来的DLBCL治疗将在很大程度上受到进步的免疫药物的影响.
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