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国际正常化比率升高对肩部全关节整形术后并发症的影响
Kevin Y Wang1, Theodore Quan2, Shrey Kapoor1
1Department of Orthopaedic Surgery, Johns Hopkins, Columbia, MD, USA.
Shoulder & elbow
|September 11, 2023
概括
术前高的INR水平显著增加了全肩关节整形术 (TSA) 后出血和肺部并发症的风险. 较高的INR值与并发症几率的逐步增加相关,这表明需要修订值准则.
科学领域:
- 整形外科手术 整形外科手术
- 麻醉学 麻醉学
- 患者安全 患者安全
背景情况:
- 出于临床和财务原因,确定全面肩关节整形术 (TSA) 并发症的术前风险因素至关重要.
- 手术前升高的国际规范化比率 (INR) 是TSA并发症的潜在风险因素.
研究的目的:
- 确定不同手术前INR水平对TSA后的术后并发症的影响.
- 评估肩部置换术后INR升高与特定不良事件之间的关联.
主要方法:
- 国家数据库被用于识别2007年至2018年间接受初级TSA治疗的患者.
- 患者被分为四个INR队列:<1.0,>1.0-1.25,>1.25-1.5,和>1.5.
- 多变量逻辑回归分析调整了人口统计和并发症,以评估并发症率.
主要成果:
- 与INR>1.0-1.25,>1.25-1.5和>1.5的患者相比,与INR<1.0.0的患者相比,术后出血需要输血的几率显著更高 (分别为1.6x,2.4x,2.8x).
- 升高的INR水平 (>1.25-1.5和>1.5) 与肺部并发症的几率大幅增加有关 (分别是7.8倍和7.0倍).
- 随着INR水平的上升,观察到与剂量相关的并发症几率逐步增加.
结论:
- 增加手术前的INR是TSA后术后出血和肺部并发症的独立风险因素.
- 目前关于TSA手术前INR值的指导方针可能需要进行调整,以更好地分层风险.
- 优化手术前的INR水平对于改善全肩关节整形手术患者的结果和安全至关重要.
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