扩大不良结果的途径,以实现纳米安全的健康模型
Laura Aliisa Saarimäki1,2, Giusy Del Giudice1,2, Dario Greco1,2,3
1Finnish Hub for Development and Validation of Integrated Approaches (FHAIVE), Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Frontiers in toxicology
|September 11, 2023
概括
将毒基因组学和表观遗传数据整合到不良结果途径 (AOP) 中,可以推进纳米安全评估. 这种方法支持One Health框架,用于评估跨物种和环境的化学风险.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 生物技术是生物技术.
背景情况:
- 越来越多的纳米产品需要强有力的安全评估,与欧盟绿色协议的安全和可持续设计 (SSbD) 框架保持一致.
- 一个健康概念为纳米安全提供了一个整体的方法,但目前的毒理学缺乏对化学生物相互作用的多层次理解.
- 化学安全评估,流行病学和生物学之间存在差距,这阻碍了"一个健康"模式的采用.
研究的目的:
- 探索多层次毒性基因组学和毒性表观遗传数据的整合到不良结果途径 (AOP) 框架中.
- 弥合不同生物领域和化学安全评估之间的脱节,以实现统一的"一健康"方法.
- 加强对纳米材料风险评估中的OMIC数据的解释和应用.
主要方法:
- 审查目前的毒理学和表观遗传学数据生成方法.
- 讨论应用不良结果途径 (AOP) 框架来整合复杂的生物数据.
- 提出一种新的毒基因组学方法,将多层次数据与AOP联系起来.
主要成果:
- 机械毒理学和奥米克学数据提供了对纳米材料生物反应的见解.
- 表观遗传数据为了解物种间适应机制提供了潜力.
- 负面结果路径 (AOPs) 提供了一个框架来定和解释这些复杂的数据.
结论:
- 将毒素基因组学和毒素表观遗传学数据整合到AOP中是推动纳米安全的一个有希望的方向.
- 这种综合方法可以支持开发化学风险评估的One Health模型.
- 拟议的战略有助于对各种物种和环境的化学安全进行评估,并与可持续发展目标保持一致.
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