静脉注射阿西克洛维尔在患有传染性单核病和免疫功能儿童的治疗效果
1Department of Infectious Diseases, Anhui Provincial Children's Hospital No. 39, Wangjiang East Road, Baohe District, Hefei 230022, Anhui, China.
American journal of translational research
|September 11, 2023
概括
与利巴维林相比,静脉注射阿西克洛维尔显著改善了感染性单核病 (IM) 的儿童的治疗结果,减少了症状和不良反应. 这种抗病毒疗法也积极调节免疫功能,显示出临床应用的希望.
科学领域:
- 儿童传染病 儿童传染病
- 抗病毒疗法 抗病毒疗法
- 免疫学 免疫学 免疫学
背景情况:
- 传染性单核病 (IM) 是儿童常见的一种病毒性疾病.
- 目前用于IM的治疗方法具有不同的疗效和副作用.
- 了解抗病毒疗法对IM免疫功能的影响至关重要.
研究的目的:
- 评估静脉注射阿西克洛维尔在儿科IM患者的临床疗效.
- 评估静脉注射阿西克洛维尔对免疫功能标记物的影响.
- 为了比较静脉注射的阿西克洛维尔与利巴维林在治疗IM时.
主要方法:
- 追溯分析98名IM儿童,分为观察 (静脉注射阿西克洛维尔) 和控制 (利巴维林) 组.
- 临床疗效,不良反应,症状恢复时间和免疫功能指数 (IgG,IgA,IgM,WBC,淋巴细胞比例) 的比较.
- 多变量逻辑回归分析以确定治疗疗效的独立风险因素.
主要成果:
- 静脉注射阿西克洛维尔的整体反应率明显高于利巴维林 (P=0.025).
- 艾西克洛维尔组从发烧,喉炎,淋巴腺病和肝壮病中恢复得更快,副作用较少 (P<0.05).
- 在治疗后,阿西克洛维尔组的IgG,IgA,IgM,WBC和淋巴细胞水平明显降低 (P<0.010).
结论:
- 静脉注射阿西克洛维尔在治疗儿科IM方面是有效的,改善了临床反应率并减少了症状的严重程度.
- 乙克洛维尔治疗与较少的不良反应和有益的免疫功能调节有关.
- 静脉注射的阿西克洛维尔显示出显著的临床价值,并保证在IM管理中得到更广泛的应用.
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