释放治疗潜力:将药物重定向和免疫疗法整合到针对各种疾病的免疫疗法
Vishakha Anand Pawar1, Anuradha Tyagi2, Chaitenya Verma3
1The University of Texas MD Anderson Cancer Center Houston, TX 77030, USA.
American journal of translational research
|September 11, 2023
概括
药物重新定位或重新定位,通过使用现有药物治疗新疾病,为新疗法提供了更快的途径. 本综述强调了将药物重定向与各种疾病的免疫疗法结合起来.
科学领域:
- 药理学 药理学是指药理学的学科.
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 药物开发 药物开发
背景情况:
- 药物再利用利用现有药物用于新的治疗指示,为新药开发提供了替代方案.
- 这一策略越来越多地应用于复杂的疾病,包括癌症,心血管疾病,神经退行性疾病和COVID-19等传染病.
研究的目的:
- 审查药物重定向策略与免疫疗法的整合,以治疗各种疾病.
- 强调将已知药物与基于免疫的疗法相结合的潜力,以提高疗效.
主要方法:
- 对有关药物重用和免疫治疗的现有文献进行系统审查.
- 对翻译方法的分析,探索药物向的病理生理机制.
- 对药物重新定位中以患者为中心的策略的评估.
主要成果:
- 药物重定向利用现有的药物特性,安全性和药理学数据,有可能加速临床试验批准.
- 在治疗各种疾病方面,已经观察到重定向药物免疫疗法的成功出现.
- 药物重新定位和免疫治疗的结合显示出对多种疾病的前景.
结论:
- 药物再利用,特别是与免疫疗法相结合时,为开发一系列疾病的治疗方法提供了可行和有效的方法.
- 对这种综合策略的进一步研究是有必要的,以优化治疗结果.
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