心血管变异性,社会人口统计和疾病生物标志物:MIDUS研究
Tara Gruenewald1, Teresa E Seeman2, Tse-Hwei Choo3
1Department of Psychology, Chapman University, Orange, CA, United States.
Frontiers in physiology
|September 11, 2023
概括
低频血压变化 (LF-BPV) 与年龄,性别和高血压有关. 这种节奏对节奏的测量不同于基于诊所的变异性,并显示了与健康结果的潜在关联.
科学领域:
- 心血管生理学心血管生理学
- 自主神经系统功能 自主神经系统功能
- 生物医学工程 生物医学工程
背景情况:
- 血压 (BP) 在多个时间尺度上表现出变化,从几个月到心脏周期.
- 血压变化 (BPV) 的传统测量方法包括访问记录 (VVV-BP) 和24小时门诊记录 (ABPV).
- 比特比特BPV,特别是低频 (LF-BPV),提供了对快速BP波动的洞察力,但需要持续监测.
研究的目的:
- 调查LF-BPV与社会人口因素 (年龄,性别,种族) 之间的关系.
- 探索LF-BPV与高血压,糖尿病和肥胖等临床疾病之间的关联.
- 检查LF-BPV与特定生物标志物和死亡风险的相关性.
主要方法:
- 在美国中年研究 (MIDUS) 的2,118名参与者中,在11分钟的休息期间计算了LF-BPV.
- 统计分析检查了LF-BPV与社会人口统计学变量之间的关联.
- 评估了LF-BPV,临床因素,生物标志物 (IL-6,s-ICAM,上腺素,皮质醇) 和死亡率之间的相关性.
主要成果:
- 随着年龄的增长,LF-BPV降低,男性比女性高;没有发现与种族或社会经济地位的关联.
- 在高血压患者中观察到升高的LF-BPV,但与其他代谢风险因素没有显著联系.
- 肺腹血压 (DBPV) 与炎症标志物和压力激素相关,并显示死亡风险降低的趋势,这取决于年龄.
结论:
- 与传统的BPV测量相比,LF-BPV与社会人口统计因素和临床条件有明显的关联.
- 这些发现突显了LF-BPV作为新型心血管风险指标的潜力.
- 需要对更大,多样化的样本进行进一步的研究,以确认这些关系和临床影响.
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