超声波向的微泡破坏通过PDE5i/NO集成来调解洞穴重塑和阴茎康复的PDE5i/NO集成
Wende Yang1, Chen Qiu2,3, Jiancheng Zhai1
1Department of Gastrointestinal Surgery The Third Affiliated Hospital of Sun Yat-sen University Guangzhou China.
Bioengineering & translational medicine
|September 11, 2023
概括
这项研究引入了一种新型的脂肪体微泡,载有西尔德纳菲尔和氧化 (NO),用于治疗洞穴神经损伤 (CNI) 后的勃起功能障碍 (ED). 超声波向的微泡破坏增强了药物输送,促进阴茎的恢复和功能性勃起.
科学领域:
- 生物医学工程 生物医学工程
- 再生医学是一种再生医学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 洞穴神经损伤 (CNI) 后的勃起功能障碍 (ED) 涉及阴茎纤维化,微血管输液受损和神经质蛋白减少.
- 目前的治疗方法,如V型化酶抑制剂 (PDE5i),由于药物积累不良和氧化 (NO) 缺乏,其疗效有限.
研究的目的:
- 开发和评估一种新型的脂质体微泡 (MB) 系统,同时提供西尔德纳菲尔和NO,用于治疗CNI诱导的ED.
- 评估超声波向MB破坏 (UTMD) 在局部传递和治疗效果方面的有效性.
主要方法:
- 装有西尔德纳菲尔和NO的脂肪体微泡的设计.
- 使用超声波向微气泡破坏 (UTMD) 在双边CNI的老鼠模型中进行向输送.
- 评估阴茎微血管输液,缺氧,氧化应激以及结构/功能参数.
主要成果:
- 通过UTMD介导的西尔德纳菲尔和NO负载的MBs的输送显著改善了阴茎的微血管输液.
- 治疗缓解了缺氧和氧化应激,激活了NO循环瓜诺辛单酸盐路径.
- 观察到内皮/肌肉组成的恢复,洞内压力的增加和神经完整性的改善,这表明逆转了重塑和功能恢复.
结论:
- 通过MBs与UTMD相结合的Sildenafil和NO的同时递送提供了一种有希望的策略,以提高神经性ED中PDE5i的疗效.
- 这种方法为CNI后的阴茎康复提供了优越的治疗选择.
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