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Metal-Ligand Bonds02:51

Metal-Ligand Bonds

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The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
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相关实验视频

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Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
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用于生物医学成像的酶响应型宏环金属复合物.

Quoc-Viet Le1, Jaiwoo Lee2, Seungbeom Ko2

  • 1Faculty of Pharmacy Ton Duc Thang University Ho Chi Minh City Vietnam.

Bioengineering & translational medicine
|September 11, 2023
PubMed
概括
此摘要是机器生成的。

这项研究引入了一种新型的酶响应性加多 (Gd) 输送系统,用于增强癌症成像. 该系统提高了MRI对比剂的安全性和瘤特异性,显示了对治疗学应用的希望.

关键词:
生物医学成像成像技术对比剂是一种对比剂.马克罗环胺的使用方法金属离子金属离子

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科学领域:

  • 生物医学工程 生物医学工程
  • 纳米技术 纳米技术
  • 放射化学 放射化学是指辐射化学.

背景情况:

  • 金属合剂对比剂对于通过MRI进行癌症诊断至关重要.
  • 由于快速清除和非特异性积累,当前的药物需要高剂量,这引发了安全问题.

研究的目的:

  • 开发一种酶响应的金属输送系统,用于向道 (Gd) 在瘤中的吸收.
  • 提高MRI对比剂的安全性和特异性.

主要方法:

  • 一种加多加载的酶响应性宏环 (Gd@ErMC) 用一个PEGylated,酶可切割的进行了工程设计.
  • 在携带瘤的小鼠体内研究使用MRI和正子发射断层扫描 (PET) 进行分布分析.
  • 进行了组织学和血清学分析以评估安全性.

主要成果:

  • Gd@ErMC证明了延长半衰期和高瘤特异性.
  • 基化外保护免受非特异性结合,而瘤部位的酶分裂选择性地释放了Gd.
  • 安全评估证实了该剂的低毒性.

结论:

  • 这种新型的酶响应性对比剂输送系统增强了瘤向和安全性.
  • 该系统显示了作为MR指导放射治疗的治疗剂的潜力.