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Updated: Jun 20, 2026

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
12:55

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Published on: February 16, 2015

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用基因编辑iPS细胞进行基因疗法,以向恶性质瘤

Ryota Tamura1, Hiroyuki Miyoshi1,2,3,4,5, Kent Imaizumi2

  • 1Department of Neurosurgery Keio University School of Medicine Shinjuku-ku, Tokyo Japan.

Bioengineering & translational medicine
|September 11, 2023
PubMed
概括

来自人类诱导的多能干细胞 (hiPSCs) 的基因组编辑的神经干细胞 (NSCs) 显示出对质母细胞瘤的增强迁移和抗瘤作用. 这种新型基因疗法方法对治疗侵入性质瘤干细胞 (GSCs) 是有前途的.

关键词:
这就是CRISPR/Cas9的作用.铁性化 (ferroptosis) 是一种基因治疗的基因疗法质母细胞瘤 (glioblastoma) 是一种移民 移民 迁移 迁移

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相关概念视频

Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...