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响应活性氧物种的双重向纳米系统促进了免疫细胞死亡,对抗乳腺癌

Asmita Banstola^1,2, Mahesh Pandit³, Ramesh Duwa¹

¹College of Pharmacy Keimyung University Daegu South Korea.

Bioengineering & translational medicine

|September 11, 2023

概括

这项研究引入了一种用于乳腺癌免疫治疗的新型纳米粒子系统. 它通过诱导癌细胞死亡和增强瘤微环境中的免疫细胞活性,有效触发抗瘤免疫反应.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
纳米技术纳米技术
材料科学材料科学材料科学

背景情况:

优化乳腺癌治疗仍然具有挑战性,抗原呈现不佳阻碍了有效的癌症免疫疗法.
开发增强免疫细胞透和激活的策略对于改善治疗结果至关重要.

研究的目的:

开发用于乳腺癌的协同免疫疗法,使用反应性氧物种 (ROS) 响应的双向纳米系统.
同时释放多克索鲁比 (DOX),R848和MIP-3α,促进免疫细胞透,免疫细胞死亡 (ICD) 和树突细胞 (DC) 成熟.

主要方法:

设计了一种双重向的,对ROS有反应的硫基甲基纳米粒子 (TKNP) 系统,载有DOX,R848和MIP-3α,并与抗PD-L1.1结合.
在乳腺癌模型中,纳米系统被评估其诱导ICD,促进DC成熟和增强免疫细胞透的能力.
机械学研究研究了瘤向,卡尔雷蒂库林 (CRT) 和HMGB1暴露,以及CD4+和CD8+T细胞的透.

主要成果:

对抗PD-L1-DOX-R848-MIP-3α/TKNP系统的内注射导致了显著的乳腺癌回归.
该纳米系统有效地向瘤组织,最大限度地提高CRT和HMGB1的暴露.
观察到内CD4+和CD8+T细胞透的显著增强.

结论:

开发的ROS响应的TKNP系统为乳腺癌提供了一个有前途的协同免疫疗法策略.
这种方法通过结合ICD,免疫细胞招募和DC成熟,有效调节瘤微环境.
双重向的纳米系统代表了有效的乳腺癌管理的潜在临床治疗策略.

关键词:

卡尔雷蒂库林是一种卡尔雷蒂库林.免疫细胞的透.免疫细胞的招募免疫细胞的招募免疫原性细胞死亡智能纳米系统是一个智能纳米系统.

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