改变大脑网络的功能连接在心理性勃起功能障碍与认知障碍相关的大脑网络的功能连接
Sitong Feng1,2, Linrui Dong1,2, Bin Yan3
1Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, People's Republic of China.
Neuropsychiatric disease and treatment
|September 11, 2023
概括
这项研究表明,心理性勃起功能障碍 (PED) 与大脑网络连接的改变有关,影响记忆和视觉空间技能等认知功能. 这些发现为儿童发育障碍认知功能障碍背后的神经机制提供了新的见解.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 精神病学是一个精神病学.
背景情况:
- 心理性勃起功能障碍 (pED) 与认知功能障碍有关.
- 以前的神经成像研究表明,在PED患者中,大脑功能连接异常.
- 导致PED认知缺陷的精确神经机制尚不清楚.
研究的目的:
- 调查儿童发育障碍认知功能障碍的潜在机制.
- 分析大规模的大脑网络及其功能连接 (FC).
- 探索认知表现和改变的大脑网络FC之间的关系.
主要方法:
- 使用了休息状态功能磁共振成像 (fMRI).
- 招募了30名pED患者和30名健康对照 (HC).
- "多森巴赫图谱"为FC分析定义了大规模的大脑网络.
主要成果:
- 对于pED患者,视觉网络中的FC降低.
- 在视觉模式和默认模式网络,视觉模式和前端对象网络以及腹部注意力和默认模式网络之间观察到减少的FC.
- 立即记忆得分与视觉网络FC正相关;视觉空间得分与腹部注意力默认模式网络FC负相关.
结论:
- 在pED的认知障碍与大规模大脑网络之间的改变FC有关.
- 这些发现为儿童发育障碍认知功能障碍的神经机制提供了新的证据.
- 视觉,默认模式,前侧双侧和腹侧注意力网络的连接性发生变化.
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