间歇性与每日维生素D补充剂在改善循环中的25(OH) D度方面的有效性:对随机对照试验的贝叶斯网络元分析
Yan Zhuang1,2, Zhe Zhu3, Peihan Chi1,2
1Department of Public Health, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Frontiers in nutrition
|September 11, 2023
概括
间歇性维生素D补充与每日摄入量一样有效,可以提高25-氧维生素D[25(OH) D]水平. 每周或每月的维生素D剂量为每日补充提供了方便和有效的替代方案.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 维生素D缺乏是一个全球性的健康问题,导致维生素D补充剂的广泛使用.
- 每日与间歇性 (每周或每月) 维生素D补充剂的比较疗效尚不清楚.
- 优化维生素D摄入策略对于公共卫生倡议至关重要.
研究的目的:
- 为了比较每日与间歇性维生素D补充剂在25-氧维生素D[25(OH) D]水平上的有效性.
- 确定最佳的剂量频率和方案,以达到目标25...OH) D度.
- 为维生素D补充策略提供基于证据的建议.
主要方法:
- 一个系统性审查和贝叶斯网络元分析 (NMA) 的116个随机对照试验 (RCTs) 涉及11,376名参与者.
- 在2020年11月之前搜索了Medline,EMBASE和Cochrane图书馆的数据库.
- 使用Cochrane协作工具评估偏差风险,并使用平均差异 (MD) 和95%置信区间 (CI) 分析有效性.
主要成果:
- 每日和间歇性维生素D补充剂都显著增加了25(OH) D度.
- 在每日补充和间歇补充组之间没有发现统计学上显著的25...OH) D度的差异.
- 在3个月内每周补充600,000 IU,显示出最高的疗效 (MD = 63 nmol/L).
- 一个月的剂量为60,000 IU (约. 建议每天使用2000 IU) 来达到最佳水平 (>75 nmol/L).
结论:
- 间歇性维生素D补充与每日剂量一样有效,可以改善25...OH) D水平.
- 间歇性治疗方案提供了一个方便的替代方案,为最佳疗效推特定的每周或每月剂量.
- 研究结果支持使用方便的间歇性维生素D补充计划来达到目标血液水平.
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