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用第一线直接作用抗病毒药物重新治疗C型肝炎

Amit Goel¹, Harshita Katiyar², Mayank²

¹Department of Hepatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.

Journal of clinical and experimental hepatology

|September 11, 2023

概括

使用一线药物,如索福斯布维尔和达克拉塔斯维尔的型肝炎病毒 (HCV) 重新治疗,当二线选择无法使用时,可以有效. 在接受这些治疗方案24周的患者中,观察到92%的高成功率.

科学领域:

肝病学肝病学是一种肝病学.
病毒学病毒学
传染性疾病传染性疾病

背景情况:

一线型肝炎病毒 (HCV) 治疗方法,包括索福斯布维尔,达克拉塔维尔,莱迪帕斯维尔或韦尔帕斯维尔,失败率为5-10%.
这项研究探讨了缺乏二线抗病毒药物的环境中的HCV再治疗策略.

研究的目的:

在初始治疗后复发的患者中,评估使用一线抗HCV药物重复治疗的疗效.
评估使用可用的一线药物用于救援疗法的可行性.

主要方法:

包括那些在基于索福斯布维尔的无干扰素治疗方案后复发的成年患者.
重新治疗涉及24周的第一线药物,通常是利巴维林,并在泛型和基因型特异性疗法之间切换.
结果被定义为12周持续的病毒反应 (SVR12),无反应或复发.

主要成果:

12名患者 (所有基因型为3) 在先前治疗后复发.
在重新治疗后,12名患者中有11名 (92%) 实现了SVR12.
两名最初没有重新治疗的患者在随后的索福斯布维尔/韦尔帕塔斯维尔/里巴维林疗程后获得了SVR12.

结论:

当二线疗法无法获得时,使用一线药物进行HCV再治疗是一种可行的选择.
结合一线药物,利巴维林和调节方案的24周重复治疗方案显示出高的成功率.
这种方法为难以治疗的HCV病例提供了有价值的救援策略.

关键词:

重新治疗HCV的方法直接作用的抗病毒药物.在C型肝炎病毒的感染中,这就是Sofosbuvir.韦尔帕塔斯维尔 (Velpatasvir) 是一个

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