溶性α-klotho与中年和老年人死亡风险之间的关联
Min-Hsiang Chuang1, Hung-Wei Wang2, Yun-Ting Huang2
1Renal Division, Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan.
Frontiers in endocrinology
|September 11, 2023
概括
可溶性α-klotho水平显示了与老年人死亡率的非线性联系. 无论是非常低的水平还是非常高的水平都与增加全因死亡风险有关.
科学领域:
- 老年学和老年医学是老年学和老年医学.
- 生物标志物和疾病风险
- 人口健康研究 人口健康研究
背景情况:
- 溶性α-klotho (α-klotho) 是一种涉及衰老和各种健康状况的蛋白质.
- 之前对α-klotho和一般人群死亡风险的研究是有限的,结果不一致.
- 了解这种关系对于确定老龄化人口健康干预的新目标至关重要.
研究的目的:
- 调查可溶性α-klotho水平与全因死亡率之间的关联.
- 在美国的中年和老年人的全国代表性样本中分析这种关系.
- 为了澄清这种关联的非线性性质.
主要方法:
- 利用了2007-2016年国家健康和营养检查调查 (NHANES) 中13,583名参与者 (年龄在40-79岁) 的数据.
- 根据血清α-klotho水平 (血囊) 将参与者分为七组.
- 将NHANES数据与国家死亡指数链接在一起,以便在2019年12月31日之前对死亡率进行跟踪,使用加权考克斯回归分析.
主要成果:
- 较低的α-klotho水平与男性性别,吸烟,年龄较大,BMI较高和EGFR较低有关.
- 更高的α-klotho水平与型肝炎病毒感染有关.
- 最低α-klotho组 (1组) 的个人死亡风险最高.
- 与第一组相比,2-6组的全因死亡风险降低了25-35%.
- 与中间组 (组4) 相比,最低 (组1) 和最高 (组7) 的α-klotho组都表现出较高的死亡风险.
结论:
- 在可溶性α-klotho水平和中年和老年美国成年人全因死亡率之间存在非线性关联.
- 最低度和最高度的α-klotho的人面临死亡风险较高.
- 这些发现凸显了α-klotho作为其全谱死亡风险的潜在生物标志物的重要性.
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