人类肠道转基因组采矿揭示了一种尚未开发的抗生素来源
Marcelo D T Torres1,2,3, Erin Brooks4, Angela Cesaro1,2,3
1Machine Biology Group, Departments of Psychiatry and Microbiology, Institute for Biomedical Informatics, Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States of America.
bioRxiv : the preprint server for biology
|September 11, 2023
概括
科学家们在人类肠道微生物群中发现了数百种新的抗生素,称为smORF编码 (SEPs),在人类肠道微生物群中. 这些新型SEP显示出强大的抗微生物活性,并有可能开发针对耐药细菌的新药.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 药物发现 药物发现 药物发现
背景情况:
- 耐药细菌对全球健康构成重大威胁,需要新的抗生素发现方法.
- 传统的抗生素发现方法正在努力跟上抗菌素耐药性的上升.
结论:
- 来自*Prevotella copri*的一种SEP,prevotellin-2的活性与polymyxin B.相似.
- 在人类肠道中发现了数百个SEP,这为对抗耐药细菌提供了一个有希望的新途径.
- 在微生物组社区重构和病原体控制方面,SEP可能发挥作用.
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