在跨诊断样本中的认知行为治疗反应的自我集中大脑预测器
Angela Fang1, Bengi Baran2, Jamie D Feusner3,4,5
1Department of Psychology, University of Washington, Seattle, WA, 98195-1525.
medRxiv : the preprint server for health sciences
|September 11, 2023
概括
大脑连接模式,而不是自我报告措施,预测认知行为疗法 (CBT) 对焦虑和强迫症障碍的反应. 这些神经成像生物标志物可以优化治疗选择,以改善患者的治疗结果.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 为了优化治疗选择,需要认知行为疗法 (CBT) 响应的生物标志物.
- 目前的行为和自我报告措施不足以预测CBT结果.
- 这项研究研究了与自我集中注意力 (SFA) 相关的大脑连接模式,作为CBT反应的潜在生物标志物.
研究的目的:
- 评估预处理和基于变化的功能连接模式作为CBT响应的生物标志物.
- 探索基于神经成像测量SFA在预测治疗改善中的实用性.
- 评估这些连接模式是否是焦虑和强迫症障碍的跨诊断.
主要方法:
- 27名患有社会焦虑障碍或身体形障碍的患者在12次认知治疗课程之前和之后接受了fMRI.
- 符合条件是基于特征自我集中注意力 (SFA) 分数的升高.
- 基于种子的静止状态功能连接性分析是使用后带皮层/前种子进行的.
主要成果:
- 种子和参与注意力和自我处理的区域之间的治疗前连接预测了更大的临床改善.
- 特定的积极和消极连接模式与症状减少有关.
- 治疗前后之间的连接变化显示出预测改善的趋势,但没有达到统计学意义.
结论:
- 治疗前的大脑功能连接,特别是与自我集中注意力相关的,作为一个有价值的神经成像生物标志物,用于预测CBT反应.
- 这些发现突出了神经成像对自我报告措施的潜力,以预测跨诊断性焦虑和强迫症患者的治疗结果.
- 这种方法可能有助于个性化心理健康障碍的治疗策略.
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