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使用多种新型非对比MRI方法对人类淋巴系统进行初步横截面调查

Swati Rane Levendovszky¹, Jaqueline Flores¹, Elaine R Peskind²

¹Department of Radiology, University of Washington School of Medicine, 1959 NE Pacific Street, Seattle, WA 98195.

bioRxiv : the preprint server for biology

|September 11, 2023

概括

非侵入性MRI方法揭示睡眠影响脑脊液 (CSF) 运动,而衰老影响脑血流和水交换. 这些发现强调了与睡眠和衰老有关的明显的淋巴系统变化.

科学领域:

神经成像是一种神经成像.
淋巴系统生理学淋巴系统生理学
睡眠和衰老研究研究

背景情况:

淋巴系统从大脑中清除废物,受睡眠和衰老的影响.
非侵入性MRI技术提供了研究淋巴功能横截面的潜力.

研究的目的:

评估两种不同的MRI方法来评估淋巴系统的各个方面.
研究淋巴功能与人类睡眠和衰老的关联.

主要方法:

基于扩散的Intravoxel Incoherent Motion (IVIM) 成像,以测量脑脊液在脑下空间 (SAS) 的运动 (伪扩散系数).
基于输液的多回声,哈达马德编码了多延迟的动脉脊柱标记 (ASL) 来评估皮质大脑血流 (CBF) 和超内皮细胞水交换 (Tex).
在正常睡眠和睡眠剥夺下对年轻人进行成像,在正常睡眠后对老年人进行成像.

主要成果:

与正常睡眠相比,IVIM在睡眠剥夺后显著减少了CSF运动 (p<0.05),但不受衰老的影响.
皮层CBF和Tex没有受到睡眠剥夺的影响,但与年轻人相比,在老年人中显著较低.
IVIM成像对睡眠生理学敏感,而ASL对衰老敏感.

结论:

IVIM成像对与睡眠相关的淋巴性CSF运输变化敏感.
多回声,多延迟ASL对与年龄相关的脑血流和血管交换变化敏感.
这些MRI方法为睡眠和衰老中的淋巴系统动态提供了独特的见解.

关键词:

在ASL中,ASL是ASL.第四十一章没有了老化的老化衰老的老化体运动 (glymphatics) 是一种运动.睡眠睡眠睡眠睡眠睡眠

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