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Updated: Jul 16, 2025

Using Sniper-Cas9 to Minimize Off-target Effects of CRISPR-Cas9 Without the Loss of On-target Activity Via Directed Evolution
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Using Sniper-Cas9 to Minimize Off-target Effects of CRISPR-Cas9 Without the Loss of On-target Activity Via Directed Evolution

Published on: February 26, 2019

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克里斯普尔混合:一种克里斯普尔介导的细胞内定向进化平台,用于RNA适应体

Qiwen Su-Tobon, Jiayi Fan, Kevin Feeney

    bioRxiv : the preprint server for biology
    |September 11, 2023
    PubMed
    概括

    研究人员开发了一种新的CRISPR系统,以进化RNA吸收体,以精确调节基因. 这种方法使哺乳动物细胞中的多个基因能够同时激活和抑制,使用新型的aptamer-RNA结合蛋白对.

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