在自上而下的电路中,具有发展上不同的架构
bioRxiv : the preprint server for biology
|September 11, 2023
概括
发育中的中部前额叶皮层 (mPFC) 显示出明显的发育开关,而不是线性强化,通过前额叶回路调节威胁反应. 这些变化使得小鼠能够采用特定年龄的行为策略.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 系统神经科学 系统神经科学
背景情况:
- 中间前额叶皮质 (mPFC) 对于决策,情绪和威胁反应至关重要,长期发展到成年早期.
- 模型表明,不成熟的mPFC努力调节快速发展的皮质下区域,影响青少年和青少年的行为.
- 目前尚不清楚如何逐渐的上下控制成熟导致非线性行为变化.
结论:
- 开发的mPFC电路经历了明显的架构变化,而不仅仅是逐步加强.
- 这些发育转变优化了电路功能,以适应特定年龄的挑战和威胁反应.
- 揭示了由电路开发驱动的非线性行为成熟机制.
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