Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Flexible and scalable inference of spatially varying correlation in spatial transcriptomics with spCorr.

Genome research·2026
Same author

CIPHER: An end-to-end framework for designing optimized aggregated spatial transcriptomics experiments.

PLoS computational biology·2026
Same author

IntegrateRigor: annotation-free integration optimization for cell identity recovery reveals cancer-immune interface niches.

bioRxiv : the preprint server for biology·2026
Same author

Cyclin-Dependent Kinase 5 Contributes to Bruton's Tyrosine Kinase Inhibitor Resistance via the IRE1α/XBP1 Axis in Mantle Cell Lymphoma.

Research square·2026
Same author

SnakeAltPromoter Facilitates Differential Alternative Promoter Analysis.

Computational and structural biotechnology journal·2026
Same author

scDesignPop generates realistic population-scale single-cell RNA-seq for power analysis, benchmarking, and privacy protection.

bioRxiv : the preprint server for biology·2026

相关实验视频

Updated: Jul 16, 2025

qPCRTag Analysis - A High Throughput, Real Time PCR Assay for Sc2.0 Genotyping
07:00

qPCRTag Analysis - A High Throughput, Real Time PCR Assay for Sc2.0 Genotyping

Published on: May 25, 2015

17.1K

剪刀QTL:超快速和强大的eGene识别方法.

Heather J Zhou1, Xinzhou Ge1,2, Jingyi Jessica Li1,3,4,5

  • 1Department of Statistics and Data Science, University of California, Los Angeles, Los Angeles, CA 90095, USA.

bioRxiv : the preprint server for biology
|September 11, 2023
PubMed
概括

剪刀QTL通过显著降低计算成本,有效地识别cis-eGenes (由本地遗传变异调节的基因). 这种新方法提供了与FastQTL相似的准确性,但速度要快得多,加速了eQTL分析.

更多相关视频

High-throughput DNA Extraction and Genotyping of 3dpf Zebrafish Larvae by Fin Clipping
10:12

High-throughput DNA Extraction and Genotyping of 3dpf Zebrafish Larvae by Fin Clipping

Published on: June 29, 2018

14.1K
Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER
14:06

Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER

Published on: June 23, 2012

15.3K

相关实验视频

Last Updated: Jul 16, 2025

qPCRTag Analysis - A High Throughput, Real Time PCR Assay for Sc2.0 Genotyping
07:00

qPCRTag Analysis - A High Throughput, Real Time PCR Assay for Sc2.0 Genotyping

Published on: May 25, 2015

17.1K
High-throughput DNA Extraction and Genotyping of 3dpf Zebrafish Larvae by Fin Clipping
10:12

High-throughput DNA Extraction and Genotyping of 3dpf Zebrafish Larvae by Fin Clipping

Published on: June 29, 2018

14.1K
Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER
14:06

Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER

Published on: June 23, 2012

15.3K

科学领域:

  • 遗传学 遗传学 是一个
  • 生物信息学是一种生物信息学.
  • 计算生物学 计算生物学

背景情况:

  • 识别cis-eGenes对于理解基因调节至关重要.
  • 像FastQTL这样的现有方法是计算密集型的,限制了它们的应用.
  • 替代方法往往缺乏FastQTL的统计能力.

研究的目的:

  • 开发一种计算效率高的 cis-eGene 识别方法.
  • 与现有的黄金标准相比,保持或提高eGene检测的准确性.
  • 为表达量化特征位置 (eQTL) 分析提供更快的替代方案.

主要方法:

  • 提出了ClipperQTL,这是一种用于eGene识别的新方法.
  • 在大样本大小 (>450) 中采用了对比策略,以减少排列.
  • 对于较小的样本大小,采用传统的基于顺序的方法,类似于FastQTL.

主要成果:

  • ClipperQTL的性能可以与FastQTL相提并论.
  • 在ClipperQTL中,对比策略将大数据集的必要排列从数千个减少到20个.
  • 采用对比策略,ClipperQTL的速度大约是500倍,采用传统方法的速度是50倍.

结论:

  • 在不影响准确性的情况下,ClipperQTL为eGene识别提供了显著的速度改进.
  • 该方法适用于eQTL研究中的大和小样本大小.
  • 对于ClipperQTL来说,一个R包是公开的.