在自闭症中表征皮层下结构异质性
David N MacDonald1,2, Saashi A Bedford1,2,3, Emily Olafson2,4
1Integrated Program in Neuroscience, McGill University.
bioRxiv : the preprint server for biology
|September 11, 2023
概括
自闭症涉及到在条纹体,状球体和质体中的异常大脑发育. 这些微妙的,特定于位置的形状差异,而不是总体体积的变化,随着年龄的变化而变化.
科学领域:
- 神经成像是一种神经成像.
- 发育神经科学的发展神经科学.
- 自闭症谱系障碍研究研究
背景情况:
- 自闭症谱系障碍 (ASD) 在大脑结构和功能中表现出显著的异质性.
- 之前在ASD中对皮层下结构 (如质体,球体和条纹体) 的神经成像研究已经产生了不一致的结果.
- 这些皮下区域对于感官处理和运动控制至关重要,这些功能在ASD中往往不典型.
结论:
- 纹状体,白色球体和质体的神经发育在ASD中异常改变.
- 这些变化表现为微妙的,取决于位置的形状变化,而不是总体体积的变化.
- 观察到的神经解剖学差异在整个寿命中是不均的,突出显示年龄是ASD神经生物学中的关键因素.
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