治疗耐药抑郁症中的情绪处理偏差背后的大脑机制
bioRxiv : the preprint server for biology
|September 11, 2023
概括
治疗耐药性抑郁症 (TRD) 涉及有偏见的情绪处理. 深度大脑刺激 (DBS) 正常化了杏仁体和前额叶皮层 (PFC) 的活动,这表明DBS可以纠正这些神经缺陷.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 抑郁症与偏见的情绪处理有关,偏爱负面信息而不是积极的信息,导致诸如无情感之类的核心症状.
- 抑郁症中这种情绪偏差的潜在神经机制仍然不太清楚.
研究的目的:
- 研究治疗耐药抑郁症 (TRD) 中偏见情绪处理的神经机制.
- 为了检查深度大脑刺激 (DBS) 对TRD患者这些神经机制的影响.
主要方法:
- 立体电脑学 (sEEG) 在情感面部评分任务中记录了TRD患者和控制者的杏仁体和前额叶皮层 (PFC) 活动.
- 分析的重点是杏仁体对悲伤和快乐面孔的反应和PFCα频段活动和杏仁体-PFC相锁定.
- 在TRD患者中,DBS前后的神经活动的比较,针对下带膜 (SCC) 和腹腔囊/腹腔条纹体 (VC/VS).
主要成果:
- 与对照人群相比,TRD患者对悲伤的面孔的早期杏仁体反应增加,对快乐的面孔的晚期杏仁体反应减少.
- 在快乐面孔处理过程中,TRD患者显示晚期PFCα带活性增加和杏仁体-PFCα相锁定.
- 在TRD患者的DBS治疗正常化了杏仁体和PFC对快乐面部的处理,扭转了治疗前观察到的非典型模式.
结论:
- 在TRD中早期的杏仁核过度活跃可能反映了负面刺激的过度活跃的自下而上的处理.
- 通过阿尔法带振荡的PFC介导的后期抑制可能会抑制TRD中的积极情绪处理,这是DBS可以逆转的模式.
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