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相关概念视频

Biosynthesis of Lipids01:29

Biosynthesis of Lipids

34
Microbial membranes exhibit remarkable diversity in lipid composition, reflecting evolutionary adaptations to various environmental conditions. The three domains of life—Bacteria, Archaea, and Eukarya—synthesize membrane lipids through distinct biosynthetic pathways, leading to fundamental structural differences that impact membrane stability, function, and adaptability.Fatty Acid-Based Lipids in Bacteria and EukaryaBacteria and eukaryotes share a common fatty acid biosynthesis...
34
Lipid Catabolism01:25

Lipid Catabolism

46
Triglycerides serve as crucial long-term energy storage molecules in microorganisms, providing a dense source of metabolic energy. Their breakdown is mediated by lipases, which hydrolyze triglycerides into glycerol and free fatty acids. Each of these components follows distinct metabolic pathways, ultimately contributing to ATP synthesis and cellular energy homeostasis.Glycerol MetabolismGlycerol, released from triglyceride hydrolysis, is phosphorylated by glycerol kinase to form...
46
Overview of Fatty Acid Metabolism01:28

Overview of Fatty Acid Metabolism

30.8K
Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
30.8K
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

1.7K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.7K
Lipid Digestion01:06

Lipid Digestion

92.0K
Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.
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Carbon-dioxide Fixation01:28

Carbon-dioxide Fixation

37
Carbon dioxide fixation in prokaryotes enables the assimilation of inorganic carbon into organic molecules, supporting biosynthetic pathways, sustaining ecosystems, and contributing to the global carbon cycle. It also has industrial applications in carbon capture and bioproduct synthesis. Autotrophic organisms rely on this process to utilize CO₂ as a carbon source in diverse environments.The Calvin CycleThe Calvin cycle is the most widespread carbon fixation mechanism, primarily used by...
37

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相关实验视频

Updated: Jul 16, 2025

Quantitative Determination of De Novo Fatty Acid Synthesis in Brown Adipose Tissue Using Deuterium Oxide
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Quantitative Determination of De Novo Fatty Acid Synthesis in Brown Adipose Tissue Using Deuterium Oxide

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进化相关的宿主和微生物通路调节脂肪脱和.

Bennett W Fox1, Maximilian J Helf1, Russell N Burkhardt1

  • 1Boyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.

bioRxiv : the preprint server for biology
|September 11, 2023
PubMed
概括
此摘要是机器生成的。

微生物群和宿主通路汇聚在NHR-49/PPARα上,以调节脂肪酸脱. 像becyp#1和bemeth#1这样的小分子激活脂肪-7表达,影响脂质代谢.

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Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
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Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans
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Quantitative Determination of De Novo Fatty Acid Synthesis in Brown Adipose Tissue Using Deuterium Oxide
07:34

Quantitative Determination of De Novo Fatty Acid Synthesis in Brown Adipose Tissue Using Deuterium Oxide

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Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
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Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans
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科学领域:

  • 脂质代谢 脂质代谢是什么
  • 分子生物学分子生物学
  • 微生物学 微生物学

背景情况:

  • 脂肪酸脱对于metazoan脂质代谢至关重要,影响膜脂质和信号分子.
  • 营养条件和微生物群调节脱酶表达的机制在很大程度上是未知的.
  • 核受体NHR-49/PPARα在调节脂质代谢方面发挥着关键作用.

研究的目的:

  • 阐明调节脂质脱的机制,以响应内源性和微生物群衍生的信号.
  • 确定参与控制C. elegans中脱酶表达的信号分子和途径.

主要方法:

  • 在β-氧化突变体 (acdh-11) 上利用非向代谢学来识别累积的代谢物.
  • 研究了核受体NHR-49/PPARα在调解代谢物诱导基因表达中的作用.
  • 对具有与微生物化合物类似活性的内源代谢物进行选.
  • 对微生物和内源性脂肪酸衍生物分析了不同的代谢途径.

主要成果:

  • 鉴定了一种微生物衍生的β-cyclopropyl脂肪酸 (becyp#1),通过NHR-49.9激活stearoyl-CoA脱酶FAT-7表达.
  • 发现一种具有类似活性的内源性β-甲基脂肪酸 (bemeth#1),来自宿主甲基转移酶fcmt-1.
  • 证明贝西普#1和贝梅特#1通过不同的途径 (分别是β-氧化和α-氧化) 代谢.
  • 表明becyp#1的生物合成依赖于细菌环氨酸合成酶,而bemeth#1来自宿主fcmt-1,可能是通过古代水平基因转移.

结论:

  • 主体和微生物进化相关的途径汇聚在NHR-49/PPARα上,以调节脂肪脱.
  • 来自宿主和微生物群的小分子信号在调节脂质代谢方面发挥着关键作用.
  • 这项研究揭示了宿主微生物相互作用的新机制,用于调节重要的代谢过程.