肠道共生细菌转移到大脑的转移
Manoj Thapa1, Anuradha Kumari1, Chui-Yoke Chin1
1Emory Vaccine Center, Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, Georgia.
bioRxiv : the preprint server for biology
|September 11, 2023
概括
肠道细菌可以通过迷走神经进入大脑,特别是在肠道失调时,可能导致神经炎症和神经退行性疾病,如阿尔茨海默氏症和帕金森氏症.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 肠-大脑轴是肠与大脑之间的通讯通道,对健康至关重要.
- 肠道失调 (微生物失衡) 越来越多地与神经系统疾病有关.
- 肠道细菌影响大脑健康的机制在很大程度上是未知的.
研究的目的:
- 为了研究肠道共生细菌如何影响大脑.
- 为了确定细菌转移到中枢神经系统的途径.
- 探索细菌转移在神经疾病中的作用.
主要方法:
- 饮食变化诱导小鼠的肠道失调和肠道透性.
- 对大脑和迷走神经中细菌存在的分析.
- 单侧宫静脉切除术,以评估迷走神经的参与.
- 与微质激活和神经蛋白聚合的相关性分析.
- 阿尔茨海默病,帕金森病和自闭症谱系障碍的小鼠模型.
主要成果:
- 在诱导失生症的小鼠和神经疾病模型中,肠道共生细菌直接转移到大脑.
- 在迷走神经中检测到细菌,但在血液或其他系统部位中没有检测到.
- 吸血术显著减少了大脑中的细菌存在.
- 细菌转位与微质激活和神经蛋白质聚合相关.
- 饮食干预逆转了细菌转位,减少了神经病理.
- 在AD,PD和ASD模型中观察到肠道失调,细菌转移和微质激活.
结论:
- 一个新的开始性细菌转移轴到大脑存在.
- 这一途径与各种神经系统疾病有关.
- 准肠道失生症可能为大脑疾病提供治疗策略.
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