从自发言语中非侵入性自动检测阿尔茨海默病:一篇评论
Xiaoke Qi1, Qing Zhou2, Jian Dong3
1School of Information Management for Law, China University of Political Science and Law, Beijing, China.
Frontiers in aging neuroscience
|September 11, 2023
概括
语音分析提供了一种非侵入性的方法来检测阿尔茨海默病 (AD). 本综述涵盖了从语音中自动检测AD的技术,重点是数据收集,特征提取和分类方法.
科学领域:
- 神经科学是一个神经科学.
- 计算语言学 计算语言学
- 生物医学工程 生物医学工程
背景情况:
- 阿尔茨海默病 (AD) 是70岁以上人群的主要死亡原因,其特点是认知能力下降,包括记忆和语言障碍.
- 艾滋病患者的语言功能障碍需要开发可访问的诊断工具.
- 基于语音的方法为早期AD检测提供了一种非侵入性,方便且具有成本效益的方法.
研究的目的:
- 系统地审查自发言语自动检测阿尔茨海默病 (AD) 的技术.
- 巩固目前在数据收集,特征提取 (声学和语言) 和AD检测系统的分类方面的方法.
- 确定基于语音的AD检测方面的挑战和未来研究方向.
主要方法:
- 对基于语音的AD检测现有文献的系统审查.
- 特征提取技术的分类,包括手工制作的声学和语言特征,以及深度嵌入特征.
- 对AD检测系统的优化策略的总结.
主要成果:
- 该审查涵盖了数据收集过程,从语音和文本中提取各种特征的方法,以及分类策略.
- 基于手工制作和深度学习的功能都被分析出了它们在AD检测中的有效性.
- 总结了用于提高系统性能的优化技术.
结论:
- 语音分析为非侵入性阿尔茨海默病检测提供了一个有希望的途径.
- 关键的挑战包括数据稀缺性,模型可解释性,可靠性和有效的多模式融合.
- 未来的研究应该专注于解决这些挑战,以提高基于语音的AD检测系统的临床实用性.
相关概念视频
Alzheimer's Disease: Overview
517
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
517
Alzheimer's Disease: Treatment
212
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
212


