自免疫脑炎后的嗅觉功能障碍取决于抗体类型和边缘MRI病理
Martin Hänsel1,2, Henning Schmitz-Peiffer1, Antje Hähner3
1Department of Neurology, University of Dresden, Dresden, Germany.
Frontiers in neurology
|September 11, 2023
概括
患有NMDAR自身免疫脑炎的患者保持正常的嗅觉功能. 然而,非NMDAR自身免疫脑炎患者经历了持续的嗅觉障碍,可能是由于边缘结构损伤.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 神经科学是一个神经科学.
背景情况:
- 自身免疫性脑炎 (AE) 可以影响边缘结构,可能损害嗅觉功能.
- 鉴别AE患者的嗅觉缺陷对于了解长期神经系统后果至关重要.
研究的目的:
- 评估和描述自免疫性脑炎后患者的嗅觉功能.
- 在AE患者中调查边缘结构参与和嗅觉性能之间的相关性.
主要方法:
- 一项病例控制研究比较了11名AE患者 (NMDAR,GAD,VGKC抗体或抗体阴性) 与12名肺炎球菌脑膜炎 (PC) 控制组.
- 嗅觉功能使用嗅探棒测试 (TDI-score) 进行评估.
- 边缘结构参与通过MRI进行评估,统计分析与TDI-score和MRI发现相关联.
主要成果:
- 在AE和PC组之间,整体嗅觉功能 (TDI-score) 是可比的.
- 与NMDAR患者相比,没有NMDAR抗体的AE患者的TDI得分和区分能力明显较低.
- 非NMDAR患者表现出更多的边缘MRI病理,与嗅觉歧视受损相关.
结论:
- 患有NMDAR自身免疫脑炎的患者表现出正常的长期嗅觉功能.
- 非NMDAR自身免疫性脑炎与持续的嗅觉功能障碍有关,可能是由于边缘结构损伤造成的.
关键词:
卡斯普尔2是什么意思这就是GAD,GAD,GAD.一个LGI1一个LGI1没有NMDAR,没有NMDAR.自身免疫性脑炎的发生.嗅觉 嗅觉是一种嗅觉.嗅觉功能障碍 嗅觉功能障碍门歧视识别测试的门歧视测试.更多相关视频
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