在冠状动脉旁路移植后接受神经肌肉电刺激治疗的患者的认知结果
Vincenzina Lo Re1, Giovanna Russelli2, Emanuele Lo Gerfo1,2
1Neurology Service, Department of Diagnostic and Therapeutic Services, IRCCS ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione), University of Pittsburgh Medical Center (UPMC), Palermo, Italy.
Frontiers in neurology
|September 11, 2023
概括
在冠状动脉旁路移植 (CABG) 后的神经肌肉电刺激 (NMES) 并没有改善认知或肌,但增强了大脑连接. 增加Klotho水平与手术后更好的记忆相关.
科学领域:
- 心血管外科心血管外科
- 神经科学是一个神经科学.
- 肌肉生理学 肌肉生理学
背景情况:
- 冠状动脉旁路移植 (CABG) 可能导致神经认知能力下降,可能与系统性炎症,肌肉损伤和不运动有关.
- 肌肉健康和神经保护之间的关系需要进行研究,以减轻术后的认知缺陷.
研究的目的:
- 为了调查是否添加神经肌肉电刺激 (NMES) 标准康复改善骨肌肉强度和神经保护性myokine表达后CABG患者.
- 探索NMES在CABG后对长期认知功能和大脑连接性的影响.
主要方法:
- 进行了一项临床试验,涉及接受标准护理加NMES的CABG后患者.
- 评估了肌肉强度,血清肌肉激素水平,认知表现和大脑功能连接 (通过MRI).
主要成果:
- 在NMES和对照组之间没有观察到认知表现或大多数血清神经保护性肌蛋白的显著差异.
- 在NMES组显示在关键大脑网络 (默认模式,前面对面,突出,感觉运动) 中功能连接性增加.
- 退院后Klotho水平的增加与延迟记忆得分的改善相关,无论治疗方式如何.
结论:
- 在这项研究中,NMES可能会增强CABG后的大脑功能连接,尽管它没有改善认知结果或肌水平.
- 克洛托在CABG后的环境中显示出潜在的神经保护作用,与改善的记忆功能相关.
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