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通过抑制表观遗传驱动的EndMT,他类药物可以改善内皮功能

Chun Liu1,2,3, Mengcheng Shen1,2,3, Wilson L W Tan1,2,3

  • 1Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.

Nature cardiovascular research
|September 11, 2023
PubMed
概括

辛瓦斯塔丁通过表观遗传来减少通过YAP信号通路驱动内皮细胞向介质细胞过渡 (EndMT) 的基因,从而改善内皮细胞功能. 这种机制可以保护心血管疾病,特别是糖尿病患者.

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