尿路病原性E.E.的表征 来自印度各个地理位置的 coli
Gulshan Kumar1,2, Yashwant Kumar1, Gaurav Kumar2
1National Salmonella and Escherichia Centre, Central Research Institute, Kasauli, Himachal Pradesh, India.
Journal of Taibah University Medical Sciences
|September 11, 2023
概括
印度的尿病原性大肠杆菌 (UPEC) 对常见抗生素具有很高的耐药性,并产生扩展光谱β-乳糖酶 (ESBL). 这些耐药的UPEC菌株具有显著的毒性因子,造成了严重的公共卫生问题.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 泌尿病原性大肠杆菌 (UPEC) 是尿路感染 (UTI) 的首要原因,占全球病例的80%以上.
- 了解UPEC的特征对于有效的尿路感染管理和打击抗菌素耐药性至关重要.
研究的目的:
- 调查印度各地UPEC菌株的流行血清型,抗生素耐药性模式和病毒性因素.
- 评估与药物耐药性相关的毒性特征的共同表达.
主要方法:
- 在UPEC菌株的血清定型中,使用微位板聚合.
- 对毒性因素的评估包括生物膜形成, siderophore 生产, colicin 释放,凝水解以及细胞表面的疏水性.
- 对20种药物抗生素耐药性概况的确定和扩展谱β-乳酸酶 (ESBL) 生产.
主要成果:
- 对安培素 (63.4%),纳利迪克酸 (63.4%) 和塞福他xime (62.1%) 观察到高耐药率.
- 印度各地区存在多种药物耐药性 (63.36%),ESBL产生 (34.1%) 和卡巴胺耐药性 (25.0%) 的显著流行.
- 常见的毒性因素包括 siderophore 生产 (67.7%),生物膜形成 (62.5%),水性 (61.2%);共同表达频繁 (69.8%).
结论:
- 在印度流通的UPEC菌株表现出高水平的抗菌素耐药性.
- 这些耐药菌株具有多样化的血清型和显著的毒性特征,突出了关键的公共卫生挑战.
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