相关实验视频
Updated: Jul 16, 2025

10:31
Antigenic Liposomes for Generation of Disease-specific Antibodies
Published on: October 25, 2018
12.4K
在患有高脂血症的患者中,对非活化COVID-19疫苗的安全性和免疫性
Lei Yang1, YaMing Liu2, Qiao Guo3
1Department of Respiratory Medicine, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Open medicine (Warsaw, Poland)
|September 11, 2023
概括
对于高脂血症患者来说,COVID-19无活化疫苗是安全的,没有增加不良事件. 然而,与健康个体相比,这种群体的抗体反应可能会减少.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 心血管医学 心血管医学
背景情况:
- 关于严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 失活疫苗在高脂血症 (HLD) 患者中的安全性和免疫性数据有限.
- 了解HLD患者的疫苗反应至关重要,因为他们患有严重COVID-19结局的风险增加.
研究的目的:
- 在患有高脂血症的患者中评估SARS-CoV-2无活化疫苗的安全性和免疫反应.
- 为了比较HLD患者和疫苗接种后健康对照人群之间的抗体水平和B细胞反应.
主要方法:
- 这是一项前性研究,涉及105名HLD患者和74名健康对照 (HC).
- 在接种疫苗后16-168天间测量抗受体结合域 (RBD) IgG和SARS-CoV-2中和抗体 (NAbs).
- 对RBD特异性B细胞和记忆B细胞的流细胞计分析.
主要成果:
- 疫苗接种后7天内,HLD患者和HC患者之间的不良事件 (AE) 或严重AE没有显著差异.
- 与HC相比,HLD患者的抗RBDIgG和NAbs抗体阳性率和抗体标位较低 (p <0.05).
- 在HLD患者中观察到RBD特异性B细胞的频率明显较低 (p = 0.040). 在特定的脂类子组中没有发现显著差异.
结论:
- 在患有高脂血症的患者中,SARS-CoV-2无活化疫苗是安全的,并且耐受性良好.
- 在接种疫苗后,HLD患者的幽默性免疫反应,包括抗体产生和特定的B细胞频率,可能受到限制.
- 需要进一步的研究来优化HLD患者的疫苗接种策略.
相关概念视频
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
696
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
696
Lipid-derived Compounds in the Human Body
4.4K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
4.4K
Lipid Absorption
516
Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
516
Blood Studies for Cardiovascular System III: Serum Lipid Profile
188
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
188
Lipids: Dietary Sources and Requirements
822
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
822
Myocarditis III: Medical Management
7
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
7

