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基于胰岛素的凝中的mupirocin纳米粒的配方和特性,用于皮肤学应用

Maysaa B Zubairi¹, Abdulkareem H Abd², Mohammed S Al-Lami³

¹Department of Pharmacology and Toxicology, College of Pharmacy, University of Basra, Basra, Iraq.

Journal of pharmacy & bioallied sciences

|September 11, 2023

概括

这项研究在以胰岛素为基础的凝中开发了mupirocin nanomicelles (MP-NM),实现了完全溶解和高捕获效率. 这种新的纳米药物输送系统显示了未来临床应用的潜力.

科学领域:

制药科学制药科学
纳米技术纳米技术
药物输送系统药物输送系统

背景情况:

穆皮罗辛 (MP) 是一种局部抗生素,具有有限的溶解性.
开发有效的纳米药物输送系统对于提高药物的有效性和患者的遵从性至关重要.
基于胰岛素的凝为药物配方提供了一个独特的矩阵.

研究的目的:

在以胰岛素为基础的凝中制定和描述mupirocin纳米粒 (MP-NM).
评估MP-NM配方的物理性质和体外药物释放.

主要方法:

使用Tween 80的溶剂蒸发方法制备了MP-NM.
基于胰岛素的凝是使用HPMC聚合物制成的.
描述包括球状直径,PDI,pH,EE和TEM分析.
进行了体外药物释放研究.

主要成果:

该MP-NM配方的球状直径为8.64 ± 0.2 nm.
获得了98.85 ± 0.01%的高捕获效率 (EE) 和均分散 (PDI,0.143 ± 0.003).
穆皮罗辛完全溶解在胰岛素基凝中,没有沉.
MP 演示了快速的第一阶级动力学释放.

结论:

这项工作介绍了第一个mupirocin nanomicelle (MP-NM) 纳米药物输送系统,使用基于胰岛素的凝.
该配方表现出极好的稳定性和药物封装.
开发的MP-NM系统对临床前和临床应用具有重大前景.

关键词:

在这种情况下,mupirocin.在80岁到80岁之间提供纳米药物的纳米药物.这是一个纳米微小的微型.

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