对于扩散期小细胞肺癌的杜尔瓦卢马布治疗后的耳病:一个病例报告
Cuifen Zhang1, Ke Wang1, Hong Zhang1
1the First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.
Clinical, cosmetic and investigational dermatology
|September 11, 2023
概括
免疫检查点抑制剂 (ICI) 可以引起与免疫相关的不良事件 (irAEs). 这一案例突出了指甲病或指甲病,作为广泛的小细胞肺癌 (ES-SCLC) 中与杜尔瓦卢马布治疗相关的罕见irrAE.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
背景情况:
- 像杜尔瓦卢马布这样的免疫检查点抑制剂 (ICI) 在治疗广泛小细胞肺癌 (ES-SCLC) 中至关重要.
- 免疫相关不良事件 (irAEs) 是ICI治疗的常见并发症.
- 病,指甲疾病,是一种不太常见但已报告的irAE.
研究的目的:
- 报告在ES-SCLC患者中第一个杜尔瓦卢马布诱导的皮病例.
- 描述这种罕见的irAE的临床表现和管理.
- 强调长期监测IRAEs的重要性.
主要方法:
- 一个ES-SCLC患者用durvalumab治疗的病例报告.
- 临床观察指甲变化 (颜色,加厚).
- 排除其他可能的原因 (感染,营养不良).
主要成果:
- 患者在杜尔瓦卢马布治疗期间出现了指甲色素和厚.
- 局部抗真菌治疗无效.
- 指甲的变化归因于杜尔瓦卢马布,而不是其他因素.
- 耳病症发生在治疗开始后的两年内.
结论:
- 耳病是ES-SCLC患者中杜尔瓦卢马布的潜在免疫相关不良事件.
- 爪子的变化可以表现为色素和加厚.
- 对于用杜尔瓦卢马布治疗的患者来说,长期随访至关重要,以检测延迟的irAEs,如皮病.
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