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口服普雷尼索隆对带桃体切除术后疼痛的影响:一项随机临床试验
Amin Shayan1, Nezammedin Berjis1, Sayed Mostafa Hashemi1
1Department of Otolaryngology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Advanced biomedical research
|September 11, 2023
概括
口服普雷迪尼索隆有效地减少了桃体切除术后的术后疼痛. 这项研究发现,与安慰剂相比,在接受口服普雷迪尼索隆的患者中,疼痛得分较低,这为这种常见手术后的疼痛管理提供了新的选择.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 桃体切除术是一种常见的耳鼻喉科手术,经常出现术后疼痛.
- 目前的术后疼痛管理策略缺乏最终的共识.
- 口服皮质类固醇对桃体切除术后疼痛的疗效尚不清楚.
研究的目的:
- 为了评估口服普雷迪尼索隆在经过桃体切除术后治疗术后疼痛的有效性.
- 在接受口服普雷迪尼索隆与安慰剂的患者中比较疼痛水平.
主要方法:
- 在两个三级保健中心进行试验,双盲,随机的临床试验.
- 用 sutures 进行桃体切除术的患者被随机分为两组.
- 实验组接受了口服普雷迪尼索隆加氨基;对照组接受了安慰剂加氨基.
- 术后疼痛每天使用视觉模拟尺度进行十天的评估.
主要成果:
- 56名患者完成了这项研究,两组年龄和性别分布相似.
- 从第1天到第10天,口服普雷迪尼索隆组的术后疼痛评分与安慰剂组相比显著较低 (P <0.05).
结论:
- 口服普雷迪尼索隆在用 sutures 进行桃体切除术后减轻术后疼痛方面表现出有效性.
- 这一发现表明,口服普雷迪尼索隆在桃体切除术后的护理中作为止痛选择具有潜在的作用.
- 进一步的研究可能会巩固口服皮质类固醇用于桃体切除术后疼痛管理的使用.
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