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血清Th1/Th2不平衡与COPD老年患者的抑郁症之间的关系及其临床影响

Teng Zhang¹, Guodong Wang², Qiang Li²

¹Department of Psychiatry, Hangzhou Seventh People's Hospital, Hangzhou, Zhejiang, China.

Technology and health care : official journal of the European Society for Engineering and Medicine

|September 11, 2023

概括

血清Th1/Th2指标的不平衡与老年COPD患者的抑郁症有关,这表明疾病进展风险更高,预后更差. 这一发现表明Th1/Th2水平可能有助于评估COPD中的抑郁症.

科学领域:

肺部医学肺部医学
精神病学是一个精神病学.
免疫学免疫学免疫学

背景情况:

慢性阻塞性肺病 (COPD) 严重影响患者的生活质量和预后,原因是有机损伤和心理障碍,如焦虑和抑郁.
这些心理并发症给家庭和社会带来了巨大的经济负担.

研究的目的:

为了研究血清Th1/Th2指标失衡和老年COPD患者的精神抑郁症之间的相关性.
分析这种相关性对临床管理和预后的影响.

主要方法:

120名老年COPD患者被分为两组:COPD与抑郁症 (SDS得分≤50) 和单独的COPD (SDS得分<50).
评估血液气体分析,肺功能 (包括FEV1),血清Th1/Th2水平 (IL-1β,IL-2,IL-6,IL-8,IL-10,TNF-α) 和COPD评估测试成绩.
利用后勤回归和ROC曲线来分析风险因素和诊断价值.

主要成果:

患有抑郁症的COPD组表现出较高的二氧化碳部分压力,COPD评估测试得分,以及血清炎症细胞因子 (IL-1β,IL-2,IL-6,IL-8,IL-10,TNF-α).
此组还显示了较低的氧化指数,FEV1,以及预测FEV1.1的百分比.
血清Th1/Th2不平衡被确定为老年COPD患者抑郁症的危险因素,临床明显恶化的间隔较短 (CID-C) 和6个月内CID-C的发病率较高.

结论:

患有慢性肺炎和抑郁症的老年患者出现肺功能减弱和血清Th1/Th2水平升高.
血清Th1/Th2指标不平衡是COPD患者抑郁症的潜在风险因素和预后因素.
患有抑郁症的COPD患者面临更高的疾病进展风险和更糟糕的预后,强调需要综合管理.

关键词:

慢性慢性肺炎是一种慢性慢性肺炎,COPD是一种慢性肺炎.Th1/Th2 的时间.抑郁抑郁症抑郁症抑郁症是一种这种不平衡是不平衡的.预后预后预后

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