在年轻成年人冠状动脉风险发展研究 (CARDIA) 中,GrimAge加速和肺功能之间的关联
Brian T Joyce1, Xuefen Chen2, Tao Gao1
1Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Epigenomics
|September 11, 2023
概括
肺功能与中年人的表观遗传衰老 (GrimAge) 有关. GrimAge还预测肺气,部分解释了肺功能与这种疾病之间的联系.
科学领域:
- 肺部医学 肺部医学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 衰老研究研究 衰老研究
背景情况:
- 肺功能随着年龄的增长而下降.
- 表观遗传衰老,或GrimAge,是衰老的生物学指标.
- 肺功能和GrimAge之间的关系尚未完全理解.
研究的目的:
- 为了研究肺功能和GrimAge之间的关联.
- 为了确定GrimAge是否预测肺气的发展.
- 探索GrimAge在肺功能和肺气之间的联系中扮演的调解角色.
主要方法:
- 有1042名参与者的前性纵向队列研究.
- 肺功能 (FEV1,FEV1/FVC) 和研究20年 (40-45岁) 的GrimAge的横截面分析.
- 在第25学年对肺气的前性评估.
主要成果:
- 肺功能测量 (FEV1和FEV1/FVC) 在研究20年显示了与GrimAge的负相关性.
- 从0-10岁的累积肺功能测量与15岁和20岁的GrimAge有关.
- 25岁时的肺显著与15岁和20岁时的灰色年龄有关.
结论:
- 肺功能与成年早期和中期的表观遗传衰老 (GrimAge) 有关.
- GrimAge是肺发育的一个预测因素.
- GrimAge部分调解了肺功能与肺气之间的关系.
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