质瘤患者的工作记忆性能与右侧前额叶皮质和默认模式网络之间的功能连接有关
Lars Smolders1,2, Wouter De Baene3, Remco van der Hofstad2
1Department of Neurosurgery, Elisabeth-TweeSteden Hospital, Tilburg, The Netherlands.
Journal of neuroscience research
|September 11, 2023
概括
质瘤患者的工作记忆性能与右侧前额叶皮质 (DLPFC) 和默认模式网络 (DMN) 之间的连接有关. 这一发现可能有助于开发用于质瘤患者管理的生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 在瘤学瘤学.
背景情况:
- 工作记忆 (WM) 依赖于健康个体的默认模式网络 (DMN) 和前端对象网络 (FPN) 活动.
- 背侧前额皮层 (DLPFC) 对WM至关重要.
- 要了解质瘤患者的WM缺陷,需要研究功能连接性.
研究的目的:
- 探索静止状态功能连接 (FC) 和WM表现在质瘤患者之间的关系.
- 具体研究DMN,FPN和DLPFC之间的FC与WM容量相关.
主要方法:
- 分析了45名手术前质瘤患者的休息状态功能性MRI数据.
- 用手术前的N-back任务来评估WM的表现.
- 根据Gordon和Yeo图谱定义的兴趣区域 (ROI) 之间的功能连接 (FC) 计算.
主要成果:
- 在右侧DLPFC和DMN的FC和WM性能之间发现了反向关系 (p=.010).
- 没有观察到左侧DLPFC或整个FPN与DMN有显著的关联.
- 结果在不同的地图集和瘤位置上一致.
结论:
- 在质瘤患者中,WM的性能可以通过静止状态fMRI测量的网络相互作用来量化.
- 这些发现支持开发用于临床治疗质瘤的生物标志物.
- 干扰DMN与质瘤患者的认知障碍有关.
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