24小时血压调节失调和眼球 perfusion 压力降低在开角玻璃眼病进展中的作用
Jesus D Melgarejo1,2,3, Jan Van Eijgen4,5, Dongmei Wei1
1Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
Journal of hypertension
|September 11, 2023
概括
平均动脉压 (MAP) 的反复下降和24小时内的高变化加快了青光眼的损伤. 这种进展会随着眼球输液压 (OPP) 低而恶化,影响视力.
科学领域:
- 眼科医生 眼科 眼科
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 受平均动脉压 (MAP) 和眼内压 (IOP) 影响的低眼 perfusion 压力 (OPP) 与玻璃眼瘤的发展有关.
- 了解24小时MAP调节失调及其对OPP的影响,对于研究青光眼的进展至关重要.
研究的目的:
- 调查24小时MAP失调,OPP和正常张力玻璃眼 (NTG) 和初级开角玻璃眼 (POAG) 患者的玻璃眼进展之间的关联.
- 量化MAP变化和下降对视野恶化的影响.
主要方法:
- 对155名NTG和110名POAG患者进行了回顾性分析,并进行了广泛的视野测试 (7000项测量).
- 24小时的门诊血压监测,以评估MAP可变性独立于平均值 (VIM) 和最低MAP下降.
- 使用多变量线性混合回归模型计算OPP (2/3 MAP - IOP) 和分析视野恶化 (平均偏差变化).
主要成果:
- 在POAG患者中,高24小时MAPVIM显著与光瘤进展有关,独立于平均24小时MAP.
- 具体的MAP滴度与估计的视野恶化相关,在POAG中范围为-2.16至-2.84dB.
- 减少OPP与高MAP变化和下降相结合,导致更严重的平均偏差恶化.
结论:
- 由于24小时的高度变化,MAP的反复和极端下降有助于青光眼损伤的进展.
- 当24小时的MAP失调与减少的OPP相吻合时,青光瘤进展的恶化会加剧.
相关概念视频
Open Angle Glaucoma: Treatment
477
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
477
Glaucoma: Overview
618
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
618
Angle Closure Glaucoma: Treatment
559
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
559
Photoreceptors and Visual Pathways
6.1K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
6.1K


