怀孕,分娩和新生儿后果在患有偏偏甲状腺症的妇女中 - 一个基于人口的研究
Alyssa Hochberg1,2, Aurelie Pare3, Ahmad M Badeghiesh4
1Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada.
Clinical endocrinology
|September 11, 2023
概括
孕产妇的慢性甲状腺功能低下症显著增加了新生儿早产,输血和先天异常的风险. 识别这种情况对于管理怀孕和新生儿后果至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 产科 产科 产科 产科 产科
- 新生儿科学 新生儿科学
背景情况:
- 关于怀孕并发症的孕产妇慢性甲状腺功能下降症数据是不确定的.
- 这项研究旨在比较患有慢性偏甲状腺功能障碍和没有慢性偏甲状腺功能障碍的母亲的怀孕,分娩和新生儿后果.
研究的目的:
- 评估慢性偏偏甲状腺症对怀孕和新生儿结局的影响.
- 确定慢性偏甲状腺功能障碍症作为潜在的不良怀孕和新生儿事件的风险因素.
主要方法:
- 基于人口的回顾性研究使用医疗保健成本和利用项目全国住院患者样本 (HCUP-NIS) 数据库 (2004-2014).
- 用多变量逻辑回归分析来控制潜在的混因素.
- 在204个患有慢性副甲状腺功能障碍的怀孕中,与没有这种疾病的9,096,584个怀孕中的结果进行了比较.
主要成果:
- 患有慢性副甲状腺功能障碍的母亲的早产率显著更高 (19.1%对7.2%) 和输血 (4.9%对1.0%).
- 患有慢性副甲状腺功能障碍的母亲产生的新生儿表现出更高的先天性异常发病率 (4.4%对0.4%).
- 怀孕年龄较小的新生儿和子宫内胎儿死亡率在两组之间是可比的.
结论:
- 这是迄今为止关于妊娠中慢性偏甲状腺功能障碍的最大研究,揭示了早产,输血和先天异常的显著增加.
- 慢性偏甲状腺功能障碍应该被确定为怀孕和新生儿并发症的危险因素.
- 需要进一步的研究来确定是否保持在目标范围内可以减轻这些风险.
相关概念视频
The Parathyroid Glands
2.2K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
2.2K
Synthesis and Functions of Calcitonin
2.0K
Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
2.0K
Hormones and Bone Tissue
2.7K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.7K
Synthesis and Regulation of Thyroid Hormones
4.7K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.7K
Functions of Thyroid Hormones
2.8K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.8K
Pathophysiology of Diabetes
980
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
980


