在状细胞病的干细胞移植后,混合的捐赠者奇默症
Niketa C Shah1, Hemalatha G Rangarajan2, Alexander Ngwube3
1Section of Pediatric Hematology/Oncology and Stem cell Transplant, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey.
Current opinion in hematology
|September 11, 2023
概括
造血干细胞移植 (HCT) 可以治愈状细胞疾病 (SCD). 在HCT后监测混合捐赠者/接受者合体是长期疾病控制和成功结果的关键.
科学领域:
- 血液学 血液学 血液学
- 移植医学 移植医学
- 遗传性血液疾病 遗传性血液疾病
背景情况:
- 状细胞疾病 (SCD) 是一种严重的血红蛋白病变,具有显著的发病率和死亡率.
- 造血干细胞移植 (HCT) 为SCD提供了一种治疗方法.
- 有关长期疾病控制的担忧存在,因为在HCT后混合的捐赠者/接受者合体化,即使是有侵略性调节.
结论:
- 对SCD的治疗干预必须旨在实现和长期保持这种最小的捐赠者混沌.
- 将成功的移植与最小化毒性的平衡至关重要,特别是在脆弱的患者群体中.
- 未来的HCT和基因疗法的进步需要强大的长期后续协议来评估混合混沌的持久性.
相关概念视频
Bone Marrow Sampling and Transplants
356
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
356
Tissue Transplantation
394
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
394
Multiple Allele Traits
34.3K
The Concept of Multiple Allelism
34.3K


