浅层与深层遗传原因对比
Adam C Smith1, Stephen M Downes1
1Philosophy Department, University of Utah, Salt Lake City, UT, USA adam.c.smith@utah.edu; s.downes@utah.edu.
The Behavioral and brain sciences
|September 11, 2023
概括
麦道尔和哈登的浅层与深层遗传原因区分可以澄清全基因组关联研究 (GWAS). 然而,GWAS只确定浅层遗传原因,类似于环境研究,他们的区别可能更适用于解释而不是原因.
科学领域:
- 遗传学 是一个遗传学.
- 科学哲学的哲学科学哲学
背景情况:
- 全基因组关联研究 (GWAS) 越来越多地用于识别与特征相关的遗传变异.
- 来自GWAS的因果关系主张在解释方面面临挑战,特别是关于遗传因果关系的深度.
- 为了应对这些挑战,Madole和Harden提出了浅层和深层遗传原因之间的区别.
研究的目的:
- 为了评估Madole & Harden的浅层与深层遗传学的实用性,在解释GWAS发现时需要区分.
- 评估GWAS是否仅限于识别浅层遗传原因.
- 要确定拟议的区分是否更适用于因果解释或原因本身.
主要方法:
- 马多尔和哈登的区别的概念分析.
- 对这种区分对GWAS方法学的影响进行批判性审查.
- 对将区分应用于遗传原因和解释的哲学评价.
主要成果:
- 浅层与深层遗传原因的区别为GWAS中的因果关系主张提供了潜在的清晰度.
- 据说GWAS主要用于识别浅层遗传原因,限制其取代环境研究的能力.
- 这种区别的适用性对于解释可能比对原因更为强烈.
结论:
- 这种区分为讨论GWASs发现的遗传因果关系的性质提供了一个有用的框架.
- 在使用GWAS来深入理解因果关系方面存在局限性,这凸显了其他研究方法的持续相关性.
- 需要进一步的哲学研究来完善在遗传学中浅层/深层原因区分的应用.
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