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Updated: Jul 16, 2025

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
11:27

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α

Published on: November 2, 2018

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细胞因子-受体-JAK2信号复合体的结构建模使用AlphaFold多元体

Irina D Pogozheva1, Stanislav Cherepanov2, Sang-Jun Park3

  • 1Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States.

Journal of chemical information and modeling
|September 11, 2023
PubMed
概括

这项研究模拟了完整的跨膜细胞因子受体复合体,揭示了连接体结合如何触发受体二分化和Janus Kinase 2 (JAK2) 激活细胞信号传导和瘤发生.

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Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens09:53

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens

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相关概念视频

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