各种内分泌干扰剂对生殖系统的影响
Agata Czarnywojtek1,2, Magdalena Borowska1, Kamil Dyrka3
1Department of Pharmacology, Poznan University of Medical Sciences, Poznan, Poland.
Endokrynologia Polska
|September 11, 2023
概括
内分泌干扰化学物质 (EDC) 和吸烟,酒精和大麻等生活方式因素对男性和女性的生殖健康和生殖腺功能产生负面影响. 了解这些影响对于生殖健康至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 生殖生物学 生殖生物学
- 毒理学 毒理学 毒理学
背景情况:
- 内分泌干扰化学物质 (EDCs) 普遍存在,并破坏生殖系统的平衡.
- 暴露于EDCs通过各种途径发生,可以在体液和组织中检测到.
- 包括吸烟,酒精和大麻使用在内的生活方式因素也显著影响生殖健康.
研究的目的:
- 审查关于EDCs和生活方式因素对生殖腺功能影响的当前知识.
- 阐明这些物质对内分泌系统的作用机制,重点关注生殖腺.
- 将主要科学数据库的发现整合到2022年5月.
主要方法:
- 使用PubMed,EMBASE,Google Scholar和Web of Science数据库进行全面的文献审查.
- 分析调查特定EDC (如BPA,酸盐) 和生活方式因素 (吸烟,酒精,大麻,咖啡因) 对生殖健康的影响的研究.
- 专注于在2022年5月之前发表的研究.
主要成果:
- 酸盐表现出抗雄激素活性,与两性抗穆勒尔激素 (AMH) 水平负相关.
- 吸烟和被动烟草暴露在生殖年期间显著导致内分泌系统疾病.
- 过度饮酒会破坏下丘脑-垂体-淋巴结核 (HPG) 轴;大量使用大麻素可能会导致类似问题.
- 咖啡因对男性生殖功能的不良影响需要进一步研究.
结论:
- EDCs和生活方式选择对生殖腺功能和整体生殖健康构成重大风险.
- 这些因素会破坏内分泌平衡,影响生育能力和生殖能力.
- 需要进一步的研究才能充分理解复杂的相互作用和暴露的长期后果.
相关概念视频
An Overview of the Endocrine System
8.5K
The endocrine system, a complex network of glands, orchestrates physiological balance within the body through the production and secretion of hormones. These hormones are chemical messengers in intercellular communication, acting as conduits between the secretory cells and distant target sites. They traverse the circulatory system by being released into the extracellular fluid, and their impact is specific to cells possessing receptors for a particular hormone.
The endocrine system collaborates...
The endocrine system collaborates...
8.5K
What is the Endocrine System?
414.6K
The endocrine system sends hormones—chemical signals—through the bloodstream to target cells—the cells the hormones selectively affect. These signals are produced in endocrine cells, secreted into the extracellular fluid, and then diffuse into the blood. Eventually, they diffuse out of the blood and bind to target cells which have specialized receptors to recognize the hormones.
414.6K
Structures of the Endocrine System
7.7K
The intricate framework of the endocrine system encompasses a diverse array of glands, with their target tissues and organs strategically distributed throughout the body. Central to this network are the endocrine glands, specialized structures that lack ducts and release hormones directly into the interstitial fluid. Notably, the hypothalamus, a vital neuroendocrine organ situated in the brain, governs neural functions and serves as a potent source of hormonal regulation. Near the hypothalamus...
7.7K
The Endocrine System
339
The endocrine system is an extensive network of glands – organs or tissues in the body that create chemicals that control many bodily functions, that secrete hormones, which are chemical messengers that play essential roles in regulating various bodily functions. These hormones are secreted into the bloodstream and travel throughout the body. They require specific receptors to convey signals to cells possessing these corresponding receptors. This complex signaling mechanism ensures that...
339
Target Cell Response to Hormones
3.1K
Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
3.1K
Major Hormones and Their Functions
485
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
485


