成年人对非类固醇抗炎药物的过敏反应:超出目前的分类范围
Pamir Çerçi1, Reşat Kendirlinan1, Suna Büyüköztürk2
1Department of Chest Diseases, Division of Allergy and Immunology, Faculty of Medicine, Ankara, Ankara University, Türkiye.
Allergologia et immunopathologia
|September 11, 2023
概括
欧洲过敏和临床免疫学会/欧洲药物过敏网络 (EAACI/ENDA) 对非类固醇抗炎药物 (NSAID) 过敏反应的分类可能不完全涵盖所有患者表现. 需要进一步的研究来完善非典型的NSAID过敏病例的分类.
科学领域:
- 临床免疫学 临床免疫学
- 药理学 药理学是指药理学的学科.
- 过敏研究研究 过敏研究
背景情况:
- 非类固醇抗炎药物 (NSAID) 的过敏反应 (HSR) 构成了重大的临床挑战.
- 现有的分类,如欧洲过敏和临床免疫学会/欧洲药物过敏网络 (EAACI/ENDA) 系统,旨在对这些反应进行分类.
- 对于NSAID HSR,EAACI/ENDA分类的实际应用性需要进行评估.
研究的目的:
- 评估EAACI/ENDA分类在NSAID过敏现实临床环境中的有用性.
- 确定目前EAACI/ENDA分类在捕获各种NSAID HSR表型方面的潜在局限性.
主要方法:
- 一项全国性的多中心研究在土耳其九家医院进行.
- 从有NSAID过敏史的966名成年患者的数据被追溯收集.
- 使用EAACI/ENDA指南对反应进行分类,并进行口腔挑测试.
主要成果:
- 乙盐酸 (ASA),青和甲米醇是最常见的NSAID触发剂.
- NSAID诱导的疹/血管 (NIUA) 是最常见的急性反应 (34.3%).
- 很大一部分患者 (17.3%) 不符合目前的EAACI/ENDA分类,在患有喘或过敏犀牛结膜炎的患者中观察到非典型的表现.
结论:
- 虽然EAACI/ENDA分类对NSAID诱导的HSR进行了分层,但可能无法完全捕捉到这些反应的频谱.
- 非典型的NSAID过敏表现,特别是在患有并发性过敏症的患者中,突出显示了对分类改进的需要.
- 建议进行进一步的研究,以加强EAACI/ENDA系统,以便更好地适应各种NSAID HSR表型.
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