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聚合物介导的纳米配方:癌症免疫治疗的有希望的策略

Simranjit Kaur¹, Adesh K Saini^1,2, Hardeep Singh Tuli¹

¹Department of Bioscience and Technology, MMEC, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, Haryana, 133207, India.

Naunyn-Schmiedeberg's archives of pharmacology

|September 11, 2023

概括

工程聚合物纳米系统增强癌症免疫疗法,使得有针对性的交付和激活免疫反应. 本综述探讨了基于聚合物的纳米药物的进展,以提高癌症治疗的有效性和安全性.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症免疫学癌症免疫学

背景情况:

基于聚合物的纳米系统为生物医学应用提供了可调节的特性.
癌症免疫编辑利用免疫系统控制瘤生长.
将纳米生物技术与免疫疗法相结合,在癌症治疗方面表现有前途.

研究的目的:

审查用于癌症免疫治疗的工程聚合物纳米系统的进展.
探索这些纳米系统与免疫治疗剂的结合.
为了突出提高临床结果的疗效和安全性.

主要方法:

纳米粒子与向剂 (抗体,连接体) 的功能化.
开发用于药物输送的聚合物纳米配方 (结合物).
研究针对瘤微环境的纳米系统.

主要成果:

聚合物纳米颗粒显示出向癌症治疗的潜力.
功能化的纳米粒子增强了对癌症的免疫反应.
使用的是经批准的聚合物,如PEG,PLGA,PCL和奇托.

结论:

结合免疫治疗的工程聚合物纳米系统提供了一个有前途的治疗策略.
有针对性的输送和免疫激活是改善癌症治疗的关键.
需要进一步的研究来优化纳米系统的临床应用.

关键词:

抗体是一种抗体.免疫细胞是免疫细胞.免疫治疗是一种免疫疗法.聚合物纳米颗粒的分子.有针对性的交付目标.瘤微环境是一个微环境.

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