生物技术生产和 hypocrellins 的潜在应用
Zhuanying Bao1, Yunchang Xie1,2, Chenglong Xu1
1Key Laboratory of Protection and Utilization of Subtropic Plant Resources of Jiangxi Province, Jiangxi Normal University, Nanchang, 330022, China.
Applied microbiology and biotechnology
|September 11, 2023
概括
本综述涵盖了通过菌根发酵生产的低素 (HYPs),详细介绍了它们的生物活性和潜在应用. 它还概述了修订后的生物合成途径和加强生产的监管机制.
科学领域:
- 自然产品化学 自然产品化学
- 生物技术是生物技术.
- 菌类学 菌类学是指菌类学.
背景情况:
- 来自真菌的烯基 (hypocrellins,HYPs) 显示出作为抗微生物,抗癌和抗病毒光动力学治疗剂的潜力.
- 自然资源有限,这引发了人们对使用Shiraia spp.的浸泡发酵的兴趣. 对于HYP生产而言.
- 在过去的十年中,通过发酵优化HYP生产取得了重大进展.
研究的目的:
- 审查 HYPs. 的菌根发酵的最新进展.
- 总结HYP的生物活性和潜在应用.
- 概述HYP的修订生物合成途径和监管机制.
主要方法:
- 关于HYP发酵和生物活性的最新出版物的审查.
- 对HYP的化学结构和分析方法的分析.
- 对基因群组安排和功能注释的修订.
- 同源序列的系统对齐.
- 关于完整的HYP生物合成途径的建议.
主要成果:
- 在HYP基因中修订的基因排列.
- 在HYP和CTB基因集群中解读了以前未知的基因的功能.
- 系统地对准HYP,CTB和其他同源序列.
- 对HYP生物合成途径的全面建议.
- 简要介绍HYP生物活性和潜在的应用.
结论:
- 菌发酵是一种可行的生物技术方法来生产HYP.
- 了解生物合成途径和代谢调节对于优化HYP产量至关重要.
- HYP对治疗应用具有显著的前景,特别是在光动力学治疗中.
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