疫苗对一生的性别差异和非特异性影响
Laura A St Clair1, Sabal Chaulagain1, Sabra L Klein1
1W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Current topics in microbiology and immunology
|September 11, 2023
概括
生物性别和年龄显著影响疫苗反应和结果. 女性通常表现出更强的免疫反应和更多的副作用,强调需要考虑这些因素在疫苗研究.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 性别和性别在健康中的作用
背景情况:
- 生物性别和年龄是免疫系统功能和疫苗反应的关键决定因素.
- 现有的研究表明,在整个生命周期内,疫苗接受度,免疫性,有效性和不良事件的性别差异显著.
- 这些特定于性别和年龄的变异在疫苗研发中经常被忽视.
研究的目的:
- 审查疫苗免疫性,有效性,反应性和整个生命周期的非特异性影响的已知性别差异.
- 突出生物性别和年龄对免疫反应对疫苗接种的影响.
- 提出将性别和年龄因素纳入未来疫苗研究的策略.
主要方法:
- 关于流行病学,临床和动物模型研究的综合文献综述.
- 对疫苗诱导的免疫反应的性别和年龄特定数据的分析.
- 综合关于疫苗接受度,免疫性,有效性,反应性和非特异性影响的研究结果.
主要成果:
- 在所有年龄组中,女性通常比男性表现出更大的疫苗诱导免疫反应.
- 免疫反应的性别差异在生殖年龄的个体中最为明显.
- 女性,特别是幼儿,在接种疫苗后报告了更多的不良和非特异性副作用.
结论:
- 性别和年龄至关重要,但经常被忽视,影响疫苗结果的因素.
- 了解这些差异可以优化疫苗设计,临床试验协议和公共卫生战略.
- 未来的疫苗研究必须纳入性别和年龄特定的分析,以提高疫苗对所有人群的有效性和安全性.
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