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通过油酸阻碍DNA聚合酶β活动,以抑制基切割修复,并诱导肝细胞中的线粒体功能障碍

Meina Wang1,2, Yannan Qi1, Yu Zhou1

  • 1Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, 1 WenYuan Road, Nanjing, 210023, China.

Cell biochemistry and biophysics
|September 11, 2023
PubMed
概括

自由脂肪酸 (FFAs) 通过抑制DNA聚合酶β (Pol β) 活性来损害DNA修复. 这导致DNA损伤和线粒体功能障碍,有助于肝脏疾病的发病.

关键词:
基础切除修复的基础切除修复的DNA聚合酶β.脂肪酸是一种脂肪酸.肥胖问题 肥胖问题油脂酸是一种油脂酸.

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