Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Immunological Memory01:23

Immunological Memory

662
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
662
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

868
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
868
T Cell Types and Functions01:24

T Cell Types and Functions

1.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.1K
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

1.8K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.8K
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

959
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
959
Humoral Immune Responses01:36

Humoral Immune Responses

72.9K
Overview
72.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Early-life Wnt4 expressing colon stromal cells orchestrate lifelong mucosal homeostasis via BMP-driven iNKT cell imprinting.

Nature communications·2026
Same author

IL-17RA signaling promotes the dedifferentiation of Paneth progenitors through ADAM17 to regenerate gut epithelium post-irradiation.

Nature communications·2026
Same author

A Video-Based Intervention Supporting Spanish-Speaking Fathers of Infants in the Neonatal Intensive Care Unit: Open-Label Pilot Study.

JMIR formative research·2025
Same author

Long-Term Intestinal Epithelial Remodeling Induced by Acute Protein-Energy Malnutrition.

bioRxiv : the preprint server for biology·2025
Same author

Growth Efficiency of Donor Human Milk Compared With Maternal Milk and Formula in Preterm Infants.

medRxiv : the preprint server for health sciences·2025
Same author

Atg16l1 and Xbp1 cooperatively protect from transcription-associated mutagenesis and small intestinal carcinogenesis.

Oncogene·2025

相关实验视频

Updated: Jul 16, 2025

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice
10:30

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice

Published on: January 25, 2017

8.9K

IL-22:免疫力的苦甜交响曲.

Jinzhi Duan1, Juan D Matute1,2, Richard S Blumberg1

  • 1Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

The Journal of experimental medicine
|September 11, 2023
PubMed
概括

白素-22 (IL-22) 降低了MHCII类表达在上皮细胞. 这一发现影响了对慢性炎症和病毒感染的理解.

科学领域:

  • 免疫学 免疫学 免疫学
  • 细胞生物学 细胞生物学
  • 分子生物学分子生物学

背景情况:

  • 表皮细胞对于维持生物屏障至关重要.
  • 在上皮细胞上的MHCII类表达会影响免疫反应.

研究的目的:

  • 为了研究白内素-22 (IL-22) 在调节MHCII类表达在上皮细胞上的作用.
  • 确定在疾病背景下通过IL-22调节MHCII类的功能后果.

主要方法:

  • 这项研究利用分子生物学技术来评估MHCII类表达.
  • 实验涉及在上皮细胞模型中操纵IL-22水平.
  • 进行了功能性测试,以评估对免疫反应的影响.

主要成果:

  • 发现介质素-22 (IL-22) 抑制了MHCII类分子在上皮细胞上的表达.
  • 这种抑制在慢性炎症疾病和病毒感染中产生了相反的效果.
  • IL-22对MHCII类的作用影响了上皮屏障的免疫监测能力.

结论:

  • IL-22作为表皮细胞MHCII类表达的关键调节剂.

更多相关视频

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
08:30

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

Published on: May 10, 2022

2.0K
A Strategy for the Study of IL-9-Producing Lymphoid Cells in the Nippostrongylus brasiliensis Infection Model
08:38

A Strategy for the Study of IL-9-Producing Lymphoid Cells in the Nippostrongylus brasiliensis Infection Model

Published on: March 3, 2023

1.4K

相关实验视频

Last Updated: Jul 16, 2025

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice
10:30

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice

Published on: January 25, 2017

8.9K
Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
08:30

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

Published on: May 10, 2022

2.0K
A Strategy for the Study of IL-9-Producing Lymphoid Cells in the Nippostrongylus brasiliensis Infection Model
08:38

A Strategy for the Study of IL-9-Producing Lymphoid Cells in the Nippostrongylus brasiliensis Infection Model

Published on: March 3, 2023

1.4K
  • 这些发现表明IL-22在控制炎症和传染病方面有不同的作用.
  • 准IL-22通路可能为表皮屏障障障碍提供治疗策略.