神经系统损伤和涉及斑马鱼幼虫中布罗夫拉尼利德的微神经调节
1Institute of Quality Standard and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing 100081, People's Republic of China.
Environmental science & technology
|September 11, 2023
概括
布罗夫拉尼利德暴露会损害斑马鱼中枢神经系统 (CNS) 的发展,影响运动和神经元的完整性. 这种杀虫剂触发神经炎症,并破坏微质-神经元通信,导致神经发育障碍.
科学领域:
- 环境毒理学环境毒理学
- 神经科学是一个神经科学.
- 生态毒理学 生态毒理学
背景情况:
- 布罗夫拉尼利德是一种广泛使用的杀虫剂,已知对水生有毒性.
- 之前的研究表明,在致命剂量时,中枢神经系统 (CNS) 有影响.
- 在环境相关度下,神经影响和机制尚不清楚.
研究的目的:
- 研究布罗夫拉尼利德在环境相关度下对斑马鱼幼虫的神经毒性作用.
- 阐明布罗夫拉尼利德诱导的神经毒性的潜在机制.
- 评估对中枢神经系统发育,神经传递和神经炎症的影响.
主要方法:
- 斑马鱼幼虫被暴露在布罗夫拉尼利德 (16.9和88.0微克/升) 中120小时.
- 评估了运动,神经递质水平和神经解剖学.
- 分析了基因转录,微质激活和炎症标志物.
主要成果:
- 在88.0μg/L下观察到显著的运动障碍,神经递质水平降低.
- 神经成像显示了轴突,髓和神经元的损伤,神经元数量减少和形态变化.
- 布罗夫拉尼利德暴露增加了微质激活,炎症性细胞因子和中性粒细胞,表明神经炎症和免疫毒性.
- 观察到与中枢神经系统发育相关的异常基因转录.
结论:
- 在环境相关的度下,布罗夫拉尼利德在斑马鱼幼虫中诱导神经发育障碍.
- 神经毒性是通过干扰微质神经元调节和诱导炎症反应来调节的神经毒性.
- 这些发现凸显了布罗夫拉尼利德对水生动物神经系统的风险.
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